Simon Wormull and Jean-Michel Sigere are poised to quit Lewes to join Sussex rivals Eastbourne Borough.
Former France under-21 international striker Sigere is in talks over a move to Priory Lane after turning down an offer from AFC Wimbledon.
Midfielder Wormull could also move across the county after becoming disillussioned with developments at the Dripping Pan since Steven King was replaced by Kevin Keehan as manager.
Borough boss Garry Wilson said: "We are in negotiations with lots of players at the moment and are also talking to last season's squad.
"We hope a high percentage of our existing squad to stay and will then add a few new faces to that."
The break-up of Lewes' title-winning squad shows no signs of slowing down with Jay Conroy becoming the latest player to leave the Rooks after joining former team-mates Paul Booth, Ian Simpemba and Gary Holloway at Havant and Waterlooville.
Conroy's exit takes the total number of departures to eight. Jamie Cade and Leon Legge moved to Tonbridge Angels, Dale Binns switched to Maidenhead and Matt Groves joined Eastleigh.
Meanwhile, Eastbourne Borough will be one of the cheapest teams to watch in the Blue Square premier division next season.
The club has announced it will be raising ticket prices to £12.50 for home games following promotion last season but that is still below the average for non-league's top flight.
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