The cheapest houses in the region are on the market in Hastings, according to a new report on the growing North-South divide.
The seaside resort is the only district in London and the South-East to have homes selling for under £20,000.
That is enough to put Hastings into the "worst" 30 districts on a deprivation table according to research conducted for the Guardian by Professor Brian Robson, head of Urban Policy Studies at Manchester University.
The other 25 regions with house values at such a low level were all in the North.
The research revealed that economic divisions between London and England's once-powerful northern cities appear to have widened in the past four years.
The research, outlined "northern sluggishness and southern ebullience" in a new league table of city prosperity.
The report says: "Despite the very welcome city centre developments in places like Leeds and Manchester, go half a mile away from the new penthouses, restaurants, offices and multi-screen cinemas and you will be in the land of the forgotten."
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