Justin Harris is a major doubt for Lewes ahead of Sunday's FA Cup first round clash with Stoke City at the Britannia Stadium.
Harris, a roofer, has suffered a bad cut to a hand at work and may require an operation.
The 25-year-old midfield hardman is seen as one of the key players in the Lewes line-up and his absence would be a major blow to the Rooks.
Manager Jimmy Quinn, whose side entertain Great Wakering Rovers in Ryman League division two tonight, said: "He is definitely out tonight and doubtful for Saturday.
"He cut it on a slate and may need an operation.
"It is a disaster for us. He has been one of our best players this year and was man-of-the-match on Saturday."
Quinn is resisting the temptation to play a makeshift side tonight in a bid to rest players ahead of the Stoke game.
Goalkeeper Ross Standen will be rested, which gives former Redhill keeper Mike Lidbury a chance in goal, but Quinn will otherwise pick his strongest available line-up.
Paul Stokes and Andy Johnson are both suspended for one game while Paul Thomsett (twisted knee) and captain Marc Cable (rib injury) are doubtful starters.
Thomsett has made a remarkable recovery from the injury he suffered ten days ago against East Thurrock.
Quinn said: "It is an incredible recovery. He trained on Saturday and is hoping to play tonight."
Stokes will be fit for Sunday after a hamstring problem but Reece Head will not recover in time from a similar injury and Quinn has confirmed Standen will be the only goalkeeper in the travelling party, which means St Leonards stopper Graham Bannatyne, who is dual-registered, will not figure.
Lewes have filled six coaches for Sunday's game and many more people are travelling by car.
There is also a coach running from the Golden Cross pub in Hove.
For more details contact 01273 413372.
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