Three guests needed medical treatment after being rescued from their burning hostel and hotel over the weekend.
A hotel resident was dragged to safety by people in neighbouring rooms.
In a separate incident, two people were rescued by firefighters and treated at the scene by paramedics when fire gutted a room at their hostel. A further 31 guests fled the building.
The hotel fire happened at the Cambridge Hotel, Cambridge Road, Eastbourne, at 9.30pm on Friday.
The three-storey building was not evacuated and the fire was under control within half-an-hour.
The man was taken to the Eastbourne District General Hospital suffering from smoke inhalation and discharged shortly afterwards.
On Sunday at 2.15am, two people were rescued from a fire in the bedroom of a hostel.
One man was pulled to safety from a first-floor balcony while another was led out of the building in Pevensey Road, Eastbourne, by firefighters.
Fire crews from Eastbourne, Pevensey and Hailsham tackled the blaze. A fire brigade spokesman said the room had been gutted by fire and the rest of the building badly smoke-logged.
Firefighters remained at the three-storey building for more than three-and-a-half hours and returned at around 8am to reinspect it for hot spots.
The cause of the blaze has not been confirmed and a fire investigation team was yesterday gathering evidence.
Comments: Our rules
We want our comments to be a lively and valuable part of our community - a place where readers can debate and engage with the most important local issues. The ability to comment on our stories is a privilege, not a right, however, and that privilege may be withdrawn if it is abused or misused.
Please report any comments that break our rules.
Read the rules hereComments are closed on this article