Terrified passengers watched as a man tried to open an airliner door at 35,000ft.
It took four members of the cabin crew to wrestle him to the floor in front of 420 passengers on the European Aviation flight from Miami to Gatwick and strap him in his seat.
The man was said to have gone berserk when he could not get his medication, which was in his suitcase in the cargo hold.
Flight delays meant he did not have access to the pills for about 15 hours.
The flight was due to take off at 6.15pm on Friday but did not leave until 9.15am on Saturday.
The man was questioned by police at Gatwick but was not arrested.
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