Lewes took some encouragement from a 6-0 drubbing at home to champions Bowdon in National League division two.
Having avoided relegation by beating Blueharts the week before, there was little riding on this game.
With the pressure off, Lewes played well in the opening exchanges and should have been 2-0 ahead before Bowdon scored.
Marnix Achterbergh went on a superb run, eventually rounded the goalkeeper but left himself too much to do with the angle, and then Carl Wright fired just over the bar with a thunderous shot.
Bowdon broke the deadlock seven minutes before half time, then scored again before the interval before running away with things in the second half.
Lewes manager Paul Benoy said: "We still had chances to get back into it in the second half but they finished it off."
In South Premier division one, Chichester lost 4-2 at home to Oxted.
Adam Beere and Andrew Savour scored for Chi.
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