The sister of Jane Longhurst today told of her frustration as the hunt for the missing teacher stretched on with no clear leads.
Sue Barnett said: "I don't like going to Brighton any more. It makes me very angry.
"Jane loved the city and its people but no one there has come forward to help with information."
She pleaded with residents: "Brighton is supposed to be a happening place. Well, make it happen.
"Jane always thought Brighton was a great place to live and the people were great - but doesn't it worry residents there that this could happen to them, to their sister, their partner?
"How would they feel if their loved one didn't turn up one day?"
Miss Barnett, 39, from Reading, said her son of 12 was suffering along with the rest of the family.
She said: "He was very close to Jane and she was always there for him, buying him fun things and being a teacher to him with his schooling.
"We're all trying to get on with our lives but Jane's disappearance is constantly on our minds."
Sussex Police have spent thousands of pounds on Operation Keen but after five weeks of investigations are no nearer solving the mystery.
They fear Jane has been kidnapped and are now treating the case as murder.
Miss Longhurst, 31, disappeared on March 14 from her home in Shaftesbury Road, Brighton, where she lived with her partner Malcolm Sentance.
A teacher at Uplands School for children with learning difficulties in Hollingdean, Brighton, Miss Longhurst played the viola in several local orchestras.
Police have searched skips, empty properties, garages, woodland and parks but are still waiting for a breakthrough.
The Argus has printed hundreds of posters and Sussex Police are offering a £5,000 reward.
Detective Inspector Chris Standard, second-in-command of Operation Keen, said despite the lack of information he was confident the case would be solved.
He said: "Put it this way, I am determined."
Anyone with information should call 0845 6070999.
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