Sussex skipper Jodie Levett makes his first start of the season when he leads out Worthing for their London One clash with London Nigerians.
The former Chichester flanker has recovered from a knee injury and takes his place in a pack which also features lock Ben McGowan, making his first start in the front side for two years in place of his brother Charlie, who has a head wound.
Outside half Stuart McLaughlan has flu and John Firkin is still out injured so Ben Dudley takes the No. 10 shirt.
Flanker Russell Carr is ruled out by a calf muscle problem while Sean Bennett, having completed a three-game suspension, is unavailable.
Coach Ian Davies admitted: "It's certainly going to be a challenge for us.
"London Nigerians play an exciting brand of rugby so we have got to get some ball security."
Lewes's home game with Bognor in London Three South East is a clash between two sides in need of a win, though for different reasons.
Defeat to a last-second penalty at Tonbridge Juddian cost Lewes the chance to keep pace with the promotion frontrunners.
It did not do Bognor any favours either, given Juddian are one of the lowly sides they must overhaul if they are to escape the drop.
Bognor have drawn their last two home matches and are desperate for a first success of the season.
Brighton will look to build on the bright attacking work they produced at leaders Maidstone last week and get their season up and running with a home win over Dartfordians.
Skipper Andy Pinnock is still out with a torn hamstring.
East Grinstead have quietly moved on to the fringes of the London Four South East promotion picture and will fancy their chances of a win at Bromley.
The winners of Crawley's home clash with Eastbourne will leave thoughts of the drop zone behind them and have their sights firmly set on mid-table.
Crawley have won their last two league games and team manager Geoff Lodge admits the wet, muddy conditions have suited their strong pack.
Second row duo Pete Baldwin and Stephen Bloxham have been given particular praise, along with the precise throwing into the lineout of hooker Tom Anstice.
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