Award-winning choreographer, Wayne McGregor is renowned for his exploration of movement.

And as the human brain is responsible for all our movements, it isn't too strange to discover he has delved into the dark recesses of neuroscience for this innovative dance collaboration.

McGregor has, in the past, experimented with pointe shoes, prostheses and basic anatomy. With this production, he puts the physical aside as he explores how the brain works in tandem with the body.

Ataxia is a medical condition affecting the body's ability to co-ordinate muscular movement.

McGregor spent some time as a research fellow at the neuroscience department at Cambridge University and, during his fellowship, pursued an interest in the dysfunctional condition, which inspired him to put together this piece.

The dance is performed by McGregor's own company, Random Dance - in residence at Sadlers Wells since 2002 - and looks into the complex interaction between body and brain. The hour-long performance shows the audience how the mind is unable to cope with sensory overload.

Right from the onset Random's normally exquisite and elegant dancers start to flail and stagger around the stage. The resultant discordant movements symbolise the progressive disintegration of the brain's functions.

The whole affair is an ambitious large-scale collaboration between McGregor and an array of industry stalwarts.

Striking designs by John Warwicker, of design collective Tomato reflect the dancers' movements through a mirrored wall and moveable transparent screens, adding an otherwordly frisson to the proceedings, and there's a commissioned score by Michael Gordon, which has been recorded by the 14-piece band, Icebreaker.

This cacophony of instruments was performed live at the inaugral Sadler Wells performance last year and is amplified to such an extent that it frays on the audience's nerves as it erupts.

Given it's degenerative subject matter, this production is not always easy to sit through but it does mark the transition for Random Dance from cutting egde fringe to international prominence.

Starts 8pm, Tickets £15/£12.50, Tel 01273 3709709