Planners are expected to approve a new medical school which has already attracted interest from hundreds of people.
The plans for part of the scheme go before Brighton and Hove councillors on Wednesday and they are being recommended to give developers the go-ahead.
The application by Brighton Healthcare NHS Trust is for a five-storey education centre including a library, lecture room, restaurant, training room, staff accommodation and plant rooms.
It would be built next to the Sussex Eye Hospital in Eastern Road at the junction with Paston Place.
The site has been occupied for many years by a 35-space car park.
The teaching block is planned as part of the new medical school being formed with the city's two universities.
Some neighbours have already objected to the scheme, which they say will be too big and will spoil a conservation area.
The Kingscliffe Society has also criticised the plant room.
Planning officer Pete Johnson said there were no problems with the basic idea of the development.
But there were concerns about some details and he hoped these could be settled before the meeting.
Councillors are also being asked to approve an application to demolish the old renal buildings at the Royal Sussex County Hospital.
They will be replaced by a multi-storey children's hospital to replace the Royal Alexandra in Dyke Road.
Councillors are being recommended to approve the scheme in principle.
The eight-storey building would linked to other departments by high-level walkways.
A petition by residents in Upper Abbey Road says the building will lead to a rise in noise and disturbance.
Mr Johnson said the council already had a planning policy which acknowledged there would be substantial redevelopment on the site.
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