Worthing crashed to their first defeat in eight games when relegation-threatened Leatherhead shocked them 3-1 at Woodside Road in division one south.
Rebels had Mark Knee back up front but failed to produce the same spark which saw them win 5-1 at Epsom and Ewell on Tuesday.
Leatherhead never looked back after Phil Ruggles gave them the lead after only eight minutes.
Worthing were forced to call up substitute keeper Matthew May for the second half after Luke Burton suffered a groin strain, and defender Tom Graves headed a Gary Young corner over before poor marking allowed Wesley Harrison to double the lead on 64 minutes.
Ruggles looked suspiciously offside eight minutes later when he made it three from six yards after Worthing failed to clear.
Ben Carrington grabb-ed the consolation five minutes from time.
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