The closure of parts of Chatham Place and New England Road for sewer repairs is causing daily traffic jams.
The work, between Seven Dials and Old Shoreham Road, is expected to last three weeks.
Westbound traffic is diverted via Old Shoreham Road and Dyke Road while eastbound traffic is using Buckingham Place, Terminus Road, Trafalgar Road, Whitecross Street and New England Street.
Work on a broken drain in London Road, opposite Tongdean Lane, will last two weeks.
Restrictions mean a diversion via Deneway and Eldred Avenue.
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