Two boys were seriously injured in a crash.
Officers said a marked police car became aware of a motorbike in the St Leonards area shortly after 1.30pm today.
It immediately made off at speed, before it collided with a number of other vehicles in London Road. The bike was later confirmed to be stolen.
The rider and passenger – both boys aged 15 and 17, from the area – have been taken to hospital with serious but not life-threatening injuries, police said.
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A spokesman for Sussex Police said: "A section of London Road in St Leonards has been closed as officers respond to the scene and motorists are urged to seek alternative routes in the meantime.
"Anyone who witnessed the collision or the vehicle being ridden in the area around the time, specifically anyone with mobile, dash cam or CCTV footage, is asked to come forward.
"You can email collision.appeal@sussex.police.uk quoting Operation Hayman.
"The incident has been referred to the Independent Office for Police Conduct (IOPC)."
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