National Highways will be carrying out resurfacing works on the A27 next week.
The work will take place on the eastbound carriageway between Falmer and the Ashcombe roundabout.
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The road will be closed overnight between 8pm until 6am for two nights starting from Monday.
National Highways said a signed diversion will be in place during these hours via, A270, A259 and A26.
People can then rejoin the A27 at the Beddingham roundabout.
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