The Conservatives are forecast to only win four seats in Sussex at the next general election.
A new nationwide poll of 18,000 people predicts Rishi Sunak and the Tories would be left with just 80 MPs, which would be their worst result in history.
A total of 18 Conservative Cabinet ministers, including Chichester MP Gillian Keegan, are among those expected to lose their seats.
The poll, conducted by Find Out Now and Electoral Calculus, predicts Labour would win 452 seats, a majority of 254, with the Liberal Democrats on 52 and the SNP with 40.
In Sussex, Labour are forecast to win several traditionally Conservative-held areas, including Chichester, Horsham and the Sussex Weald constituency, as well as Crawley, Worthing and Hastings.
The Liberal Democrats are expected to win the redrawn Mid Sussex constituency for the first time in more than 100 years. The party is also forecast to win in Lewes and Eastbourne.
Despite Labour hoping to defeat the Greens in Brighton Pavilion, the party is expected to hold their only seat in Parliament with a comfortable majority. The Greens are also forecast to win a second seat in Parliament in Bristol.
Forecast result for Sussex constituencies
- Arundel and South Downs: Conservative hold
- Bexhill and Battle: Conservative hold
- Bognor Regis and Littlehampton: Conservative hold
- Brighton Kemptown and Peacehaven: Labour hold
- Brighton Pavilion: Green hold
- Chichester: Labour gain from Conservative
- Crawley: Labour gain from Conservative
- East Grinstead and Uckfield: Conservative hold
- East Worthing and Shoreham: Labour gain from Conservative
- Eastbourne: Liberal Democrat gain from Conservative
- Hastings and Rye: Labour gain from Conservative
- Horsham: Labour gain from Conservative
- Hove and Portslade: Labour hold
- Lewes: Liberal Democrat gain from Conservative
- Mid Sussex: Liberal Democrat gain from Conservative
- Sussex Weald: Labour gain from Conservative
- Worthing West: Labour gain from Conservative
Martin Baxter, founder of Electoral Calculus, said: “The public seem even more disenchanted with the Conservatives under Rishi Sunak than they were with John Major in 1997.
“A Labour landslide looks increasingly likely and Labour voters want nationalisation, increased public spending and higher taxes.
“The next election could have a seismic impact on British politics as the recent Conservative era crashes to a close.”
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