A man suffered serious "puncture wounds" and a woman fell from a window during an "altercation".
Police said the man, in his 40s, was hurt during an incident in Farm Road, Hove, at about 8am on Sunday.
A woman in her 30s was found critically injured nearby after reportedly falling from a window.
A 39-year-old man has now been charged with grievous bodily harm and grievous bodily harm with intent.
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Sussex Police Detective Sergeant Victoria Thornton-Green said: "Following a combined effort from numerous teams across the division, we have now charged and remanded a man in relation to the offences.
"Thank you to those who have assisted our enquiries so far and we urge any outstanding witnesses or anyone with information to come forward and make a report."
Stewart Kamande of Farm Road, Hove, appeared in court on Tuesday and has been remanded in custody. He is next due to appear in court on February 14.
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