A vehicle has collided with a railway bridge.
The bridge was struck in Pulborough.
The train line between Horsham and Barnham is closed as a result.
Trains running through these stations may be delayed or cancelled.
A spokesman for Southern Rail said: "No trains can run between Horsham and Barnham until further notice."
Trains between Littlehampton and London Victoria may be diverted via Hove and no trains will call at Christ's Hospital, Billingshurst, Pulborough, Amberley and Arundel.
Disruption is expected until 3pm.
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