Albion fans were in high spirits after Chelsea boss Graham Potter had his unbeaten start smashed by a 4-1 defeat at the hands of his former club.
The Seagulls raced into a commanding half-time lead, with two own goals compounding the misery of the former Albion coach, who took up the managerial role at Stamford Bridge last month.
Brighton supporters gave Potter a hostile reception in his first return to the Amex since quitting the club, with booing and mocking taunts of "you're getting sacked in the morning".
Albion players fed off the hostile energy of their fans, quickly taking control of the contest during the blistering start to the match, in which chants of "Potter, what's the score?" grew louder.
The remarkable result at the raucous stadium was the club's first victory under Roberto De Zerbi and the first win against Chelsea since 1933.
Speaking after the match, Potter said he had nothing to apologise for after his transfer to Chelsea seven weeks ago.
He said: "I look over when they were fourth from bottom in the Premier League, probably the third worst team. There's a lot of money been raised in terms of player sales and there are a lot of good players on the pitch.
"I hope for their sake the next managers do as good a job and that's brilliant for them."
Seagulls' manager De Zerbi said that he had found a new "family" in Brighton after the Russian invasion of Ukraine forced him to leave his previous job as coach at Shakhtar Donetsk.
He said: "Today I am very happy for myself and for my staff because we have been through eight really tough months.
"I have to be thankful with the players of Brighton, with the club, how they have welcomed me and how I felt straight away since the first moment that they saw me.
"To find again a family, an atmosphere that is letting you feel like part of the environment, it's something very nice and I have to be very thankful to Brighton."
Albion now sit in eighth place in the Premier League, below Fulham but above Liverpool.
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