EMERGENCY services were called to a crash on the A27 last night.
The dual carriageway was closed in both directions after the incident between Falmer and Lewes.
Images from the scene showed the wreckage of vehicles and debris strewn across the road.
It is reported the crash involved "multiple vehicles".
One vehicle appeared to have been flipped over onto its roof, while another appeared to have ended up on its side.
UPDATE on this crash: Two men dead in horror A27 crash as police make arrests
The police said the westbound carriageway was reopened, but it is understood the crash took place on the eastbound carriageway where motorists may still be affected by delays.
A27 CRASH FALMER TO LEWES LAST NIGHT
Sussex Police said: “We are in attendance at a road traffic collision on the A27 between Falmer and the Ashcombe Roundabout.
“The eastbound carriageway remains closed however the westbound carriageway has since re-opened.
“We are advising motorists to avoid the area and seek an alternative route.”
Images from the A27 this morning (Saturday, May 1) show long queues of vehicles on the eastbound carriageway already.
One passenger who contacted The Argus said a horse was being moved from one trailer to another.
Traffic was static on the dual carriageway, with reports of tailbacks for at least two miles.
Accident investigation work is underway and vehicles are being recovered.
For a full update on this crash click here: Horror on the A27 as two men are killed in crash between Brighton and Lewes
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